Systems configured to locate a photonic device disposed in a living subject, and related apparatuses and methods

ABSTRACT

In an embodiment, a system includes a biocompatible photonic device configured for disposal within a living subject and a location-indicating aid associated with the photonic device. The location-indicating aid is configured to facilitate locating the biocompatible photonic device within the living subject. Related apparatuses and methods of use are also disclosed.

CROSS-REFERENCE TO RELATED APPLICATIONS

The present application is related to and claims the benefit of theearliest available effective filing date(s) from the following listedapplication(s) (the “Related Applications”) (e.g., claims earliestavailable priority dates for other than provisional patent applicationsor claims benefits under 35 USC §119(e) for provisional patentapplications, for any and all parent, grandparent, great-grandparent,etc. applications of the Related Application(s)).

RELATED APPLICATIONS

For purposes of the USPTO extra-statutory requirements, the presentapplication constitutes a continuation-in-part of U.S. patentapplication Ser. No. 12/283,911, entitled SYSTEMS CONFIGURED TO TRANSMITOPTICAL POWER SIGNALS TRANSDERMALLY OUT OF A LIVING SUBJECT, AND DEVICESAND METHODS, naming RODERICK A. HYDE, MURIEL Y. ISHIKAWA, DENNIS J.RIVET, ELIZABETH A. SWEENEY, LOWELL L. WOOD, JR., AND VICTORIA Y. H.WOOD as inventors, filed 15 Sep. 2008, which is currently co-pending, oris an application of which a currently co-pending application isentitled to the benefit of the filing date.

The United States Patent Office (USPTO) has published a notice to theeffect that the USPTO's computer programs require that patent applicantsreference both a serial number and indicate whether an application is acontinuation or continuation-in-part. Stephen G. Kunin, Benefit ofPrior-Filed Application, USPTO Official Gazette Mar. 18, 2003, availableat http://www.uspto.gov/web/offices/com/sol/og/2003/week11/patbene.htm.The present Applicant Entity (hereinafter “Applicant”) has providedabove a specific reference to the application(s) from which priority isbeing claimed as recited by statute. Applicant understands that thestatute is unambiguous in its specific reference language and does notrequire either a serial number or any characterization, such as“continuation” or “continuation-in-part,” for claiming priority to U.S.patent applications. Notwithstanding the foregoing, Applicantunderstands that the USPTO's computer programs have certain data entryrequirements, and hence Applicant is designating the present applicationas a continuation-in-part of its parent applications as set forth above,but expressly points out that such designations are not to be construedin any way as any type of commentary and/or admission as to whether ornot the present application contains any new matter in addition to thematter of its parent application(s).

All subject matter of the Related Applications and of any and allparent, grandparent, great-grandparent, etc. applications of the RelatedApplications is incorporated herein by reference to the extent suchsubject matter is not inconsistent herewith.

SUMMARY

In an embodiment, a system includes a biocompatible photonic deviceconfigured to be disposed within a living subject and alocation-indicating aid associated with the photonic device. Thelocation-indicating aid is configured to facilitate locating thebiocompatible photonic device within the living subject.

In an embodiment, an apparatus configured for disposal within a livingsubject includes a photonic device configured to (1) receive one or moreoptical power signals transmitted transdermally into the living subjectand convert the one or more optical power signals into electricalenergy; or (2) convert electrical energy into one or more optical powersignals transdermally transmittable out of the living subject. Theapparatus also includes a location-indicating aid configured tofacilitate locating the photonic device within the living subject. Theapparatus further includes a biocompatible packaging enclosing at leastthe photonic device.

In an embodiment, a method includes transmitting one or more firstsignals to a living subject. The method further includes, responsive tothe transmitting, receiving one or more second signals transmitted fromthe living subject indicative of a location of a photonic devicedisposed within the living subject.

In an embodiment, a method includes receiving one or more first signalstransmitted from a living subject. The method also includes targeting anoptical-electrical converter disposed within the living subject based atleast partially on information associated with the one or more firstsignals. The method further includes transmitting one or more opticalpower signals transdermally into the living subject and to the targetedoptical-electrical converter.

In an embodiment, a method includes transmitting one or more signalsfrom a living subject that are indicative of a location of anoptical-electrical converter disposed within the living subject. Themethod also includes receiving one or more optical power signals withthe optical-electrical converter, which are transmitted transdermallyinto the living subject responsive to the transmitting. The methodfurther includes converting the one or more optical power signals intoelectrical energy using the optical-electrical converter.

In an embodiment, a method includes receiving a query at a transceiverassociated with a photonic device, wherein the transceiver and thephotonic device are disposed within a living subject. The method furtherincludes, responsive to the receiving the query, transmitting locationinformation about the photonic device transdermally out of the livingsubject from the transceiver.

In an embodiment, a method includes providing location information abouta location of a photonic device disposed within a living subject.

In an embodiment, a method includes receiving one or more first signalstransmitted from a living subject. The method also includes locating anelectrical-optical converter disposed within the living subject based atleast partially on information associated with the one or more firstsignals. The method further includes receiving one or more optical powersignals transmitted transdermally out of the living subject and to anexternal device.

The foregoing is a summary and thus may contain simplifications,generalizations, inclusions, and/or omissions of detail; consequently,the reader will appreciate that the summary is illustrative only and isNOT intended to be in any way limiting. Other aspects, features, andadvantages of the devices and/or processes and/or other subject matterdescribed herein will become apparent after reading the teachings setforth herein.

BRIEF DESCRIPTION OF THE FIGURES

FIG. 1 is a functional block diagram of an embodiment of a systemincluding a biocompatible photonic device disposed within a livingsubject and a location-indicating aid configured to facilitate locatingthe biocompatible photonic device.

FIG. 2 is an enlarged plan view of an embodiment of a technique forlocating an optical-electrical converter disposed within a livingsubject in which a target is positioned on or below skin of the livingsubject and in proximity to the optical-electrical converter.

FIG. 3 is an enlarged plan view of an embodiment of clothing to be wornby a living subject that includes one or more indicia located to be inproximity to the optical-electrical converter when worn by the livingsubject.

FIG. 4 is a functional block diagram of an embodiment of a system thatemploys a transceiver disposed within a living subject, which isconfigured to transdermally transmit one or more location-encodingsignals indicative of a location of a optical-electrical converterdisposed within the living subject.

FIG. 5 is a functional block diagram of an embodiment of a systemcomprising a biocompatible apparatus disposed within a living subjectincluding an electrical-optical converter configured to convertelectricity from at least one internal power source to one or moretransdermally transmittable optical power signals, and a retroreflectorpositioned in proximity to the electrical-optical converter tofacilitate locating the electrical-optical converter.

DETAILED DESCRIPTION

Embodiments disclosed herein are directed to systems configured tolocate a photonic device (e.g., an optical-electrical converter or anelectrical-optical converter) disposed in a living subject, apparatusesconfigured to be disposed in a living subject including a photonicdevice and a location-indicating aid configured to facilitate locatingthe photonic device in a living subject, and methods of locating aphotonic device disposed in the living subject. In the followingdetailed description, reference is made to the accompanying drawings,which form a part hereof. In the drawings, similar symbols typicallyidentify similar components, unless context dictates otherwise. Theillustrative embodiments described in the detailed description,drawings, and claims are not meant to be limiting. Other embodiments maybe utilized, and other changes may be made, without departing from thespirit or scope of the subject matter presented herein.

FIG. 1 is a functional block diagram of an embodiment of a system 100including a biocompatible photonic device disposed within a livingsubject and a location-indicating aid configured to facilitate locatingthe biocompatible photonic device. Referring to FIG. 1, the system 100includes a biocompatible apparatus 102 configured to be disposed withina living subject 103, such as being embedded in tissue, muscle, or boneof a human being. The apparatus 102 includes an optical-electricalconverter 104 (e.g., one or more photodiodes), a retroreflector 106positioned at least proximate to an optical receiving surface of theoptical-electrical converter 104, and an energy-storage device 108(e.g., a battery or a capacitive device) coupled to receive and storeelectricity received from the optical-electrical converter 104. Forexample, the retroreflector 106 may be configured as a corner cube, areflective/refractive optical device, or another suitable reflectivestructure configured to reflect electromagnetic radiation away from theoptical-electrical converter 104 and generally in the direction fromwhich it was emitted. As will be discussed in more detail below, theretroreflector 106 functions as a location-indicating aid thatfacilitates locating the optical-electrical converter 104 disposedwithin the living subject 103 from outside of the living subject 103.

Still referring to FIG. 1, the apparatus 102 further includes at leastone device 110, and control circuitry 112 coupled to the at least onedevice 110 and the energy-storage device 108. The at least one device110 may be configured as a number of different biomedical devices. Forexample, the at least one device 110 may be configured as at least oneof a drug delivery device, a micro-electro-mechanical device, a boneextension device, a biosensor, a neurostimulator, or other suitablebiomedical device. The control circuitry 112 is configured to controldistribution of electricity from the energy-storage device 108 to the atleast one device 110 as one or more electrical power signals 114 thatpower the at least one device 110 and the operation of the at least onedevice 110. The control circuitry 112 may be powered by its owndedicated power source or may be configured to use a small amount ofpower from the energy-storage device 108 for power.

The optical-electrical converter 104, retroreflector 106, energy-storagedevice 108, at least one device 110, and control circuitry 112 may beconfigured to be disposed in the living subject 103, such as by beingsized for being disposed within the living subject 103 or biocompatiblewith the living subject 103. For example, the optical-electricalconverter 104, retroreflector 106, energy-storage device 108, at leastone device 110, and control circuitry 112 may be compactly enclosed in abiocompatible protective packaging 115 to package one or more componentsof the apparatus 102. In an embodiment, the optical-electrical converter104, retroreflector 106, energy-storage device 108, at least one device110, and control circuitry 112 may each be individually enclosed inseparate biocompatible packaging sections.

The system 100 may further include a selectively positionable externaldevice 116 (e.g., a hand-held device) having an optical power source 118(e.g., one or more light-emitting diodes, lasers, or other suitablelight-emitting devices) configured to output one or more optical signals120, an optical receiver 122 (e.g., one or more photodiodes) suitablefor receiving and converting to electricity location-indicating signals124 reflected from the retroreflector 106, control circuitry 126 coupledto the optical power source 118 and optical receiver 122, and a userinterface 128 coupled to the control circuitry 126. For example, theuser interface 128 may be configured as a keypad, touch screen, or othersuitable interface that allows the living subject 103 or other user tocontrol the operation of the external device 116. As an example, theexternal device 116 may be configured as a hand-held device.

Generally, location information about a location of theoptical-electrical converter 104 disposed within the living subject 103may be provided via the one or more reflected location-indicatingsignals 124. According to an embodiment of an operational method, theone or more optical signals 120 may be transmitted to the living subject103, responsive to the transmitting, the one or more reflectedlocation-indicating signals 124 may be received, the optical-electricalconverter 104 disposed within the living subject 103 may be targetedbased at least partially on the received location-indicating signals124, and one or more optical power signals may be transmittedtransdermally into the living subject 103 and to the targetedoptical-electrical converter 104.

Still referring to FIG. 1, the operation of the system 100 is describedin more detail below. In operation, the optical power source 118 outputsthe one or more optical signals 120 as one or more electromagnetic beamsat the living subject 103 that are transdermally transmitted throughtissue of the living subject 103, through the biocompatible protectivepackaging 115, and to the retroreflector 106. For example, the one ormore optical signals 120 may exhibit at least one infrared or visiblepeak wavelength that is transdermally transmittable through tissue ofthe living subject 103. When the one or more optical signals 120irradiate the retroreflector 106, at least one of the one or moreoptical signals 120 is reflected from the retroreflector 106 as the oneor more location-indicating signals 124, transmitted transdermally outof the living subject 103, and received by the optical receiver 122. Theoptical receiver 122 converts the one or more received reflectedlocation-indicating signals 124 to one or more electrical signals, andan indication may be provided on the user interface 124 that the one ormore optical signals 120 successfully targeted the optical-electricalconverter 104. When the one or more optical signals 120 are off target,a weak and diffuse reflected signal may be reflected from tissue of theliving subject 103 and received by the optical receiver 122 or noreflected signal may be received indicative of the one or more opticalsignals 120 not successfully targeting the retroreflector 106. In anembodiment, the external device 116 may be placed in proximity to theretroreflector 106 and abut exterior tissue of the living subject 103.In an embodiment, the power of the one or more optical signals 126 maybe sufficient so that the external device 116 may be positioned remotefrom the living subject 103 and the retroreflector 106 andoptical-electrical converter 104 therein.

Responsive to receiving the one or more reflected location-indicatingsignals 128 and locating the optical-electrical converter 104, theoptical power source 118 may be aimed at the located optical-electricalconverter 104 to target it and output one or more optical power signals120′ having a significantly higher intensity than that of the one ormore optical signals 120 for powering the at least one device 110 of theapparatus 102. The beam size of the one or more optical power signals120′ may be substantially greater than that of the retroreflector 106 sothat a relatively large portion of the beam is received by an opticalreceiving surface of the optical-electrical converter 104, while only arelatively small portion is reflected back toward the external device116. The one or more optical power signals 120′ are transmittedtransdermally into the living subject 103 and received by theoptical-electrical converter 104. The received one or more optical powersignals 120′ are converted to electricity that may be stored by theenergy-storage device 108, and transmitted to the at least one device110 as one or more electrical power signals under the control of thecontrol circuitry 112 for powering the at least one device 110. In anembodiment, the optical-electrical converter 104 may be configured toselectively convert specific wavelengths of the one or more opticalpower signals 120′ to electricity.

In the illustrated embodiment, the retroreflector 106 is disposed withinthe living subject 103 and enclosed in the biocompatible protectivepackaging 115. However, in one or more embodiments, the retroreflector106 may be positioned externally, such on the skin of the living subject103, or on or in clothing worn by the living subject 103.

As previously discussed, the optical-electrical converter 104,retroreflector 106, energy-storage device 108, at least one device 110,and control circuitry 112 may be enclosed in the biocompatibleprotective packaging 115 that is at least partially transparent to theone or more optical signals 120 and optical power signals 120′ output bythe external device 116 for locating or powering the at least onedevice. The biocompatible protective packaging 115 may be formed from anumber of different biocompatible polymeric materials, such as at leastone of polyxylene, polyethylene, poly(ethylene oxide), polyurethane, orpoly(butylene terephthalate). The biocompatible protective packaging 115may also be formed from a number of different biocompatible ceramics,such as silicate-based ceramics. In an embodiment, the biocompatibleprotective packaging 115 may be in the form of a biocompatible coatingmade from at least one of the aforementioned biocompatible polymeric orceramic materials and formed over a relatively less biocompatiblehousing that provides structural support for the biocompatible coatingor a housing formed from at least one of the aforementionedbiocompatible materials.

FIG. 2 is an enlarged plan view of an embodiment of a technique forlocating the optical-electrical converter 104 disposed within the livingsubject 103 in which a target 200 is positioned on or below skin 202 ofthe living subject 103 and in proximity to the optical-electricalconverter 104. In the embodiment shown in FIG. 2, the retroreflector 106shown in FIG. 1 may be omitted. The target 200 may include one or moreindicia, such as a tattoo or other suitable marking that is applied tothe skin 202 of the living subject and located in proximity to theoptical-electrical converter 104 that is disposed below the skin 202.Thus, the target 200 generally marks a location of theoptical-electrical converter 104 within the living subject 103.

In practice, the one or more optical power signals 120′ output by theexternal device 116 may be directed generally at the target 200 so thatthe one or more optical power signals 120′ are transmitted transdermallythrough the skin 202 and other tissue or muscle, and received by theunderlying optical-electrical converter 104. As previously describedwith respect to the embodiment shown in FIG. 1, the received one or moreoptical power signals 120′ may be converted to electricity by theoptical-electrical converter 104, stored in the energy-storage device108 (FIG. 1), and transmitted to the at least one device 110 (FIG. 1)under the control of the control circuitry 112 (FIG. 1).

Although the illustrated embodiment shown in FIG. 2 employs one or moreindicia 200 applied to the skin 202 of the living subject 103, othertypes of indicia may be used. For example, in an embodiment, a markermade from a material (e.g., a polymeric material) that is at leastpartially transmissive to the one or more optical power signals 120 andvisible through the skin 202 may be disposed on the optical-electricalconverter 104 and under the skin 202.

FIG. 3 is an enlarged plan view of an embodiment of clothing 300 to beworn by the living subject 103 that includes one or more indicia 302located to be in proximity to the optical-electrical converter 104 whenworn by the living subject 103. In the embodiment shown in FIG. 3, theretroreflector 106 shown in FIG. 1 may be omitted. The one or moreindicia 302 may be one or more symbols, such as embroidery, an inkmarking, a metal or plastic element, or other suitable identifyingfeature that forms part of the clothing 300. When the clothing 300 isworn by the living subject 103, the one or more indicia 302 arepositioned in proximity to the optical-electrical converter 104 that isdisposed within the living subject. Thus, the one or more indicia 302generally marks a location of the optical-electrical converter 104within the living subject 103.

In practice, the one or more optical power signals 120′ output by theexternal device 116 may be directed generally at the one or more indicia302 so that the one or more optical power signals 120′ are transmittedtransdermally through the clothing 300 and the living subject 103 to bereceived by the underlying optical-electrical converter 104. Theclothing 300 may be made from a material that is substantiallytransparent to one or more peak wavelengths of the one or more opticalpower signals 120′. As previously described with respect to theembodiment shown in FIG. 1, the received one or more optical powersignals 120′ may be converted to electricity by the optical-electricalconverter 104, stored in the energy-storage device 108 (FIG. 1), andtransmitted to the at least one device 110 (FIG. 1) under the control ofthe control circuitry 112 (FIG. 1).

FIG. 4 is a functional block diagram of an embodiment of a system 400that employs a transceiver disposed within a living subject that isconfigured to transdermally transmit one or more location-encodingsignals indicative of a location of an optical-electrical converterdisposed within the living subject. The system 400 includes abiocompatible apparatus 402 configured to be disposed within the livingsubject 103, such as being embedded in tissue, muscle, or bone of ahuman being. The apparatus 402 includes an optical-electrical converter404 (e.g., one or more photodiodes), an energy-storage device 406 (e.g.,a battery or a capacitive device) coupled to receive and storeelectricity received from the optical-electrical converter 404, at leastone device 408 coupled to the energy-storage device 406, a transceiver410, and control circuitry 412 coupled to the energy-storage device 406,the at least one device 408, and the transceiver 410. The at least onedevice 410 may be configured as at least one of a drug delivery device,a micro-electro-mechanical device, a bone extension device, a biosensor,a neurostimulator, or other suitable biomedical device. The controlcircuitry 412 is configured to control distribution of electricity fromthe energy-storage device 406 to the at least one device 408 as one ormore electrical power signals 414 that power the at least one device408, and control the operation of the at least one device 408 and thetransceiver 410. The various components of the apparatus 402 may beenclosed either collectively or individually in a biocompatible packingsimilar to or the same as the packaging 115 previously described in theembodiment shown in FIG. 1.

The system 400 may further include a selectively positionable externaldevice 416 having an optical power source 418 (e.g., one or morelight-emitting diodes, lasers, or other suitable light-emitting devices)configured to output one or more optical power signals 420, atransceiver 422 configured to output one or more request signals 424 tothe transceiver 410 disposed in the living subject 103 and process oneor more location-encoding signals 426 output from the transceiver 410responsive to the request/query 424, control circuitry 428 coupled tothe optical power source 418 and transceiver 422, and a user interface430 coupled to the control circuitry 428. For example, the userinterface 428 may be configured as a keypad, touch screen, or othersuitable interface that allows the living subject 103 or other user tocontrol the operation of the external device 116.

Generally, location information about a location of theoptical-electrical converter 404 disposed within the living subject 103may be provided via the one or more location-encoding signals 426 outputfrom the transceiver 410 disposed in the living subject 103. Accordingto an embodiment of an operational method, the one or morelocation-encoding signals 426 that are transmitted from the livingsubject 103 may be received, the optical-electrical converter 404 may betargeted/located based at least partially on information associated withthe one or more received location-encoding signals 426, and one or moreoptical power signals may be transmitted transdermally into the livingsubject 103 and to the optical-electrical converter 404 to power the atleast one device 408. According to another embodiment of an operationalmethod, the request/query 424 may be transmitted to the living subject103 and, responsive to the transmitting, the one or morelocation-encoding signals 426 indicative of the location of theoptical-electrical converter 404 may be received. From anotherperspective and according to another embodiment, the transceiver 422 mayreceive the request/query 424 and, responsive to the request/query 424,location information about the optical-electrical converter 404 may betransmitted transdermally out of the living subject 103.

Still referring to FIG. 4, the operation of the system 400 is describedin more detail below. In operation, the transceiver 422 of the externaldevice 416 may be directed according to input via the user interface 430to output the one or more request signals 424, which are transmittedtransdermally into the living subject 103 and received by thetransceiver 410 disposed in the living subject 103. Responsive to theone or more request signals 424, the transceiver 410 outputs the one ormore location-encoding signals 426 that have location information of theoptical-electrical converter 404 encoded therein to the transceiver 422.The one or more location-encoding signals 426 are transmittedtransdermally out of the living subject 103. For example, the one ormore request signals 424 or location-encoding signals 426 may be one ormore radio-frequency signals or other optical-frequency signals that mayexhibit at least one infrared, visible, or non-visible peak wavelength.Further, such one or more request signals 424 or location-encodingsignals 426 may be encrypted.

Based at least partially on the received one or more location-encodingsignals 426, the control circuitry 428 may compute a beam path anddirect the optical power source 418 to output the one or more opticalpower signals 420 at a location on the living subject 103 so that theoptical-electrical converter 404 receives the one or more optical powersignals 420 that are transdermally transmitted through the livingsubject 103. For example, the optical power source 418 may includebeam-steering provisions, such as at least one of a diffraction grating,a micro-electro-mechanical scanner, an acoustic-optical device, or anelectro-optical device configured to selectively steering the one ormore optical power signals 420 based on the computed beam path. The oneor more optical power signals 420 are transmitted transdermally throughthe living subject 103 and received by the optical-electrical converter404, which converts the one or more optical power signals 420 toelectricity that may be stored by the energy-storage device 406. Aspreviously described, the control circuitry 412 may direct theenergy-storage device 406 to transmit the one or more electrical powersignals 414 to power the at least one device 408.

In an embodiment, the transceiver 410 may be replaced by a transmitterand the transceiver 422 may be replaced by a receiver. The transmittermay be configured to transmit the one or more location-encoding signals426 periodically or continuously. Such periodically or continuouslytransmitted one or more location-encoding signals 426 may be received bythe receiver of the external device 416 and the control circuitry 428may compute the target information for the one or more optical powersignals 420 based at least partially on the location information encodedin the one or more location-encoding signals 426. In another embodiment,the transceiver 410 may include a radio frequency identification (RFID)tag and the transceiver 422 may be configured to interrogate the RFIDtag and receive location information about the optical-electricalconverter 404.

FIG. 5 is a functional block diagram of an embodiment of a system 500configured to transmit one or more optical power signals transdermallyout of a living subject to power at least one external device. Thesystem 500 includes an internal optical power transmitter 501 configuredto be disposed within a living subject 103, such as being embedded intissue, muscle, or bone of a human being. The internal optical powertransmitter 501 includes a power source 502, an electrical-opticalconverter 504 operably coupled to the power source 502 to receiveelectricity (e.g., one or more electrical signals) therefrom, andcontrol circuitry 505 configured to control distribution of electricityfrom the power source 502 to the electrical-optical converter 504 andthe operation of the electrical-optical converter 504. The power source502, electrical-optical converter 504, and control circuitry 505 may beconfigured to be disposed in a living subject 103, such as by beingsized for being disposed in the living subject 503 or beingbiocompatible with the living subject 503 and housed individually orcollectively in a suitable biocompatible packaging similar to or thesame as the biocompatible protective package 115 of FIG. 1. Theelectrical-optical converter 504 is configured to convert at least aportion of the electricity received from the power source 502 into oneor more optical power signals 510 that are transmittable through and outof tissue of the living subject 503 and have a power of at least about10 μW. In more specific embodiments, the power of the one or moreoptical power signal 510 output by the electrical-optical converter 504may range from about 10 μW to about 10 W, about 10 μW to about 1 mW,about 1 mW to about 100 W, and about 100 mW to about 1 W.

According to various embodiments, the power source 502 may include anenergy storage device, such as a battery or a capacitive device. In anembodiment, the power source 502 may include an electricity generatorconfigured to convert internal body energy of the living subject 103 toelectrical energy. For example, the electricity generator may include atleast one of a fluid-flow generator configured to convert internal bodyfluid motion into electricity, a fluid-pressure generator configured toconvert internal fluid pressure into electricity, a muscle-motiongenerator configured to convert internal muscle motion into electricity,an acceleration-motion generator configured to convert acceleration ofthe living subject 103 into electricity, or a thermal-electric generatorconfigured to convert internal body heat into electricity.

The system 500 further includes a selectively positionable externaldevice 116 for locating the electrical-optical converter 504 disposedwithin the living subject 103. Because the structure and functionalityof the external device 116 was previously described above, anexplanation of the structure and functionality is not repeated in theinterest of brevity. In practice, the external device 116 may output oneor more optical signals 120 that are reflected from the retroreflector506 as one or more reflected location-indicating signals 510. Aspreviously described, when the one or more optical signals 120successfully target the retroreflector 506, the intensity of the one ormore reflected location-indicating signals 510 is indicative of theretroreflector 506 being successfully targeted and a location of theelectrical-optical converter 504 may be ascertained.

After locating the electrical-optical converter 504, an external device512 may be positioned to receive one or more optical power signals 513output by the electrical-optical converter 504. The one or more opticalpower signals 513 may exhibit at least one infrared, visible, ornon-visible peak wavelength. The external device 512 may include apersonal electronic device, such as a cell phone, personal dataassistant, a video game device, or an electronic medical device. Theexternal device 512 includes an optical-electrical converter 514 (e.g.,one or more photodiodes) configured to convert the received one or moreoptical power signals 513 into one or more electrical power signals 516.For example, the optical-electrical converter 514 may be integrated withor separate from the at least one external device 512. In someembodiments, the optical-electrical converter 514 may be associated witha receiving aperture (e.g., one or more collimation lenses, one or morereflectors, or other focusing optics) that direct the one or moreoptical power signals 513 to the underlying optical-electrical converter514 or focus the one or more optical power signals 513 so thatsubstantially all of the optical power is received by theoptical-electrical converter 514. The external device 512 furtherincludes control circuitry 518 operably coupled to theoptical-electrical converter 514 and configured to control the operationof the at least one external device 512 responsive to receiving theconverted one or more electrical power signals 516.

In operation, electrical energy within the living subject 103 isconverted into the one or more optical power signals 513, which aretransmitted out of the living subject 103 with, for example, a power ofat least about 10 μW. More specifically, the electrical-opticalconverter 504 transmits the one or more optical power signals 513transdermally through and out of the living subject 103 responsive toinstructions from the control circuitry 505, which are received by theoptical-electrical converter 514 of the external device 512. Forexample, the control circuitry 505 may be pre-programmed to direct theelectrical-optical converter 504 to output the one or more optical powersignals 513 at specific times throughout the day. The one or moreoptical power signals 513 are received by the optical-electricalconverter 514, which converts the one or more optical power signals 513to one or more electrical power signals 516. The one or more electricalpower signals 516 may be used to power the external device 512. Forexample, the control circuitry 518 receives the one or more electricalpower signals 516 and uses the one or more electrical power signals 516to power and control the operation of the external device 512.

In an embodiment, the external devices 116 and 512 may be integratedinto a single device for simplicity. For example, a hand-held electronicdevice may be integrated with the external device 116 so that thelocation of the electrical-optical converter 504 can be ascertained tofacilitate accurately receiving the one or more optical power signals513 that can power the hand-held electronic device. It is alsocontemplated that internal optical power transmitter 501 may include atransceiver and used in conjunction with the external device 416 forlocating the electrical-optical converter 504.

Although the illustrated embodiment shown in FIG. 5 employed aretroreflector as a location-indicating aid, in other embodiments, thetechniques shown and described with respect to FIG. 4 may be employed.For example, a transceiver may be included in the internal optical powertransmitter configured to transmit one or more location-encoding signalsresponsive to a request/query transmitted transdermally into the livingsubject from a transceiver incorporated into the external device 116.

Various other embodiments for the internal optical power transmitter 501are disclosed in U.S. patent application Ser. No. 12/283,911, which wasincorporated by reference above.

The reader will recognize that the state of the art has progressed tothe point where there is little distinction left between hardware andsoftware implementations of aspects of systems; the use of hardware orsoftware is generally (but not always, in that in certain contexts thechoice between hardware and software can become significant) a designchoice representing cost vs. efficiency tradeoffs. The reader willappreciate that there are various vehicles by which processes and/orsystems and/or other technologies described herein can be effected(e.g., hardware, software, and/or firmware), and that the preferredvehicle will vary with the context in which the processes and/or systemsand/or other technologies are deployed. For example, if an implementerdetermines that speed and accuracy are paramount, the implementer mayopt for a mainly hardware and/or firmware vehicle; alternatively, ifflexibility is paramount, the implementer may opt for a mainly softwareimplementation; or, yet again alternatively, the implementer may opt forsome combination of hardware, software, and/or firmware. Hence, thereare several possible vehicles by which the processes and/or devicesand/or other technologies described herein may be effected, none ofwhich is inherently superior to the other in that any vehicle to beutilized is a choice dependent upon the context in which the vehiclewill be deployed and the specific concerns (e.g., speed, flexibility, orpredictability) of the implementer, any of which may vary. The readerwill recognize that optical aspects of implementations will typicallyemploy optically-oriented hardware, software, and or firmware.

The foregoing detailed description has set forth various embodiments ofthe devices and/or processes via the use of block diagrams, flowcharts,and/or examples. Insofar as such block diagrams, flowcharts, and/orexamples contain one or more functions and/or operations, it will beunderstood by those within the art that each function and/or operationwithin such block diagrams, flowcharts, or examples can be implemented,individually and/or collectively, by a wide range of hardware, software,firmware, or virtually any combination thereof. In one embodiment,several portions of the subject matter described herein may beimplemented via Application Specific Integrated Circuits (ASICs), FieldProgrammable Gate Arrays (FPGAs), digital signal processors (DSPs), orother integrated formats. However, those skilled in the art willrecognize that some aspects of the embodiments disclosed herein, inwhole or in part, can be equivalently implemented in integratedcircuits, as one or more computer programs running on one or morecomputers (e.g., as one or more programs running on one or more computersystems), as one or more programs running on one or more processors(e.g., as one or more programs running on one or more microprocessors),as firmware, or as virtually any combination thereof, and that designingthe circuitry and/or writing the code for the software and or firmwarewould be well within the skill of one of skill in the art in light ofthis disclosure. In addition, the reader will appreciate that themechanisms of the subject matter described herein are capable of beingdistributed as a program product in a variety of forms, and that anillustrative embodiment of the subject matter described herein appliesregardless of the particular type of signal bearing medium used toactually carry out the distribution. Examples of a signal bearing mediuminclude, but are not limited to, the following: a recordable type mediumsuch as a floppy disk, a hard disk drive, a Compact Disc (CD), a DigitalVideo Disk (DVD), a digital tape, a computer memory, etc.; and atransmission type medium such as a digital and/or an analogcommunication medium (e.g., a fiber optic cable, a waveguide, a wiredcommunications link, a wireless communication link, etc.).

In a general sense, the various embodiments described herein can beimplemented, individually and/or collectively, by various types ofelectro-mechanical systems having a wide range of electrical componentssuch as hardware, software, firmware, or virtually any combinationthereof; and a wide range of components that may impart mechanical forceor motion such as rigid bodies, spring or torsional bodies, hydraulics,and electro-magnetically actuated devices, or virtually any combinationthereof. Consequently, as used herein “electro-mechanical system”includes, but is not limited to, electrical circuitry operably coupledwith a transducer (e.g., an actuator, a motor, a piezoelectric crystal,etc.), electrical circuitry having at least one discrete electricalcircuit, electrical circuitry having at least one integrated circuit,electrical circuitry having at least one application specific integratedcircuit, electrical circuitry forming a general purpose computing deviceconfigured by a computer program (e.g., a general purpose computerconfigured by a computer program which at least partially carries outprocesses and/or devices described herein, or a microprocessorconfigured by a computer program which at least partially carries outprocesses and/or devices described herein), electrical circuitry forminga memory device (e.g., forms of random access memory), electricalcircuitry forming a communications device (e.g., a modem, communicationsswitch, or optical-electrical equipment), and any non-electrical analogthereto, such as optical or other analogs. Those skilled in the art willalso appreciate that examples of electro-mechanical systems include butare not limited to a variety of consumer electronics systems, as well asother systems such as motorized transport systems, factory automationsystems, security systems, and communication/computing systems. Thoseskilled in the art will recognize that electro-mechanical as used hereinis not necessarily limited to a system that has both electrical andmechanical actuation except as context may dictate otherwise.

In a general sense, the various aspects described herein which can beimplemented, individually and/or collectively, by a wide range ofhardware, software, firmware, or any combination thereof can be viewedas being composed of various types of “electrical circuitry.”Consequently, as used herein “electrical circuitry” includes, but is notlimited to, electrical circuitry having at least one discrete electricalcircuit, electrical circuitry having at least one integrated circuit,electrical circuitry having at least one application specific integratedcircuit, electrical circuitry forming a general purpose computing deviceconfigured by a computer program (e.g., a general purpose computerconfigured by a computer program which at least partially carries outprocesses and/or devices described herein, or a microprocessorconfigured by a computer program which at least partially carries outprocesses and/or devices described herein), electrical circuitry forminga memory device (e.g., forms of random access memory), and/or electricalcircuitry forming a communications device (e.g., a modem, communicationsswitch, or optical-electrical equipment). The subject matter describedherein may be implemented in an analog or digital fashion or somecombination thereof.

The herein described components (e.g., steps), devices, and objects andthe discussion accompanying them are used as examples for the sake ofconceptual clarity. Consequently, as used herein, the specific exemplarsset forth and the accompanying discussion are intended to berepresentative of their more general classes. In general, use of anyspecific exemplar herein is also intended to be representative of itsclass, and the non-inclusion of such specific components (e.g., steps),devices, and objects herein should not be taken as indicating thatlimitation is desired.

With respect to the use of substantially any plural and/or singularterms herein, the reader can translate from the plural to the singularand/or from the singular to the plural as is appropriate to the contextand/or application. The various singular/plural permutations are notexpressly set forth herein for sake of clarity.

The herein described subject matter sometimes illustrates differentcomponents contained within, or connected with, different othercomponents. It is to be understood that such depicted architectures aremerely exemplary, and that in fact many other architectures can beimplemented which achieve the same functionality. In a conceptual sense,any arrangement of components to achieve the same functionality iseffectively “associated” such that the desired functionality isachieved. Hence, any two components herein combined to achieve aparticular functionality can be seen as “associated with” each othersuch that the desired functionality is achieved, irrespective ofarchitectures or intermedial components. Likewise, any two components soassociated can also be viewed as being “operably connected,” or“operably coupled,” to each other to achieve the desired functionality,and any two components capable of being so associated can also be viewedas being “operably couplable,” to each other to achieve the desiredfunctionality. Specific examples of operably couplable include but arenot limited to physically mateable and/or physically interactingcomponents and/or wirelessly interactable and/or wirelessly interactingcomponents and/or logically interacting and/or logically interactablecomponents.

In some instances, one or more components may be referred to herein as“configured to.” The reader will recognize that “configured to” cangenerally encompass active-state components and/or inactive-statecomponents and/or standby-state components, etc. unless context requiresotherwise.

In some instances, one or more components may be referred to herein as“configured to.” The reader will recognize that “configured to” cangenerally encompass active-state components and/or inactive-statecomponents and/or standby-state components, unless context requiresotherwise.

While particular aspects of the present subject matter described hereinhave been shown and described, it will be apparent to those skilled inthe art that, based upon the teachings herein, changes and modificationsmay be made without departing from the subject matter described hereinand its broader aspects and, therefore, the appended claims are toencompass within their scope all such changes and modifications as arewithin the true spirit and scope of the subject matter described herein.Furthermore, it is to be understood that the invention is defined by theappended claims. In general, terms used herein, and especially in theappended claims (e.g., bodies of the appended claims) are generallyintended as “open” terms (e.g., the term “including” should beinterpreted as “including but not limited to,” the term “having” shouldbe interpreted as “having at least,” the term “includes” should beinterpreted as “includes but is not limited to,” etc.). It will befurther understood by those within the art that if a specific number ofan introduced claim recitation is intended, such an intent will beexplicitly recited in the claim, and in the absence of such recitationno such intent is present. For example, as an aid to understanding, thefollowing appended claims may contain usage of the introductory phrases“at least one” and “one or more” to introduce claim recitations.However, the use of such phrases should not be construed to imply thatthe introduction of a claim recitation by the indefinite articles “a” or“an” limits any particular claim containing such introduced claimrecitation to inventions containing only one such recitation, even whenthe same claim includes the introductory phrases “one or more” or “atleast one” and indefinite articles such as “a” or “an” (e.g., “a” and/or“an” should typically be interpreted to mean “at least one” or “one ormore”); the same holds true for the use of definite articles used tointroduce claim recitations. In addition, even if a specific number ofan introduced claim recitation is explicitly recited, such recitationshould typically be interpreted to mean at least the recited number(e.g., the bare recitation of “two recitations,” without othermodifiers, typically means at least two recitations, or two or morerecitations). Furthermore, in those instances where a conventionanalogous to “at least one of A, B, and C, etc.” is used, in generalsuch a construction is intended in the sense the convention (e.g., “asystem having at least one of A, B, and C” would include but not belimited to systems that have A alone, B alone, C alone, A and Btogether, A and C together, B and C together, and/or A, B, and Ctogether, etc.). In those instances where a convention analogous to “atleast one of A, B, or C, etc.” is used, in general such a constructionis intended in the sense the convention (e.g., “a system having at leastone of A, B, or C” would include but not be limited to systems that haveA alone, B alone, C alone, A and B together, A and C together, B and Ctogether, and/or A, B, and C together, etc.). Virtually any disjunctiveword and/or phrase presenting two or more alternative terms, whether inthe description, claims, or drawings, should be understood tocontemplate the possibilities of including one of the terms, either ofthe terms, or both terms. For example, the phrase “A or B” will beunderstood to include the possibilities of “A” or “B” or “A and B.”

With respect to the appended claims, the recited operations therein maygenerally be performed in any order. Examples of such alternateorderings may include overlapping, interleaved, interrupted, reordered,incremental, preparatory, supplemental, simultaneous, reverse, or othervariant orderings, unless context dictates otherwise. With respect tocontext, even terms like “responsive to,” “related to,” or otherpast-tense adjectives are generally not intended to exclude suchvariants, unless context dictates otherwise.

While various aspects and embodiments have been disclosed herein, thevarious aspects and embodiments disclosed herein are for purposes ofillustration and are not intended to be limiting, with the true scopeand spirit being indicated by the following claims.

1. A system, comprising: a biocompatible photonic device configured tobe disposed within a living subject; and a location-indicating aidassociated with the photonic device and configured to facilitatelocating the biocompatible photonic device within the living subject. 2.The system of claim 1, wherein the location-indicating aid includes areflective structure configured to reflect electromagnetic radiationaway from the biocompatible photonic device to indicate a locationthereof.
 3. The system of claim 2, wherein the reflective structureincludes a retroreflector.
 4. The system of claim 2, wherein thebiocompatible photonic device includes an optical-electrical converterhaving an optical receiving surface, and wherein the reflectivestructure is at least proximate to the optical receiving surface.
 5. Thesystem of claim 1, wherein the location-indicating aid includes a deviceconfigured to transmit one or more location-encoding signalstransdermally out of the living subject encoding a location of thebiocompatible photonic device.
 6. The system of claim 5, wherein the oneor more location-encoding signals include one or more radio-frequencysignals.
 7. (canceled)
 8. (canceled)
 9. The system of claim 5, whereinthe one or more location-encoding signals include one or more opticalsignals.
 10. (canceled)
 11. (canceled)
 12. The system of claim 5,wherein the device is configured to transmit the one or morelocation-encoding signals responsive to receiving a location requestfrom an external device.
 13. The system of claim 12, wherein theexternal device includes an optical power source configured to outputone or more optical power signals that are transdermally transmittableinto the living subject responsive to receiving the one or morelocation-encoding signals.
 14. The system of claim 1, further comprisingan optical power source positionable externally to the living subjectand configured to output one or more optical power signals that aretransdermally transmittable into the living subject.
 15. (canceled) 16.(canceled)
 17. The system of claim 1, wherein the location-indicatingaid includes clothing configured to be worn by a living subject, theclothing having one or more indicia located to be positioned inproximity to the biocompatible photonic device when worn by the livingsubject.
 18. The system of claim 17, wherein the clothing istransmissive to one or more optical power signals having at least oneinfrared peak wavelength, and wherein the biocompatible photonic deviceincludes an optical-electrical converter configured to convert the atleast one infrared peak wavelength into one or more electrical signals.19. The system of claim 1, wherein the location-indicating aid includesone or more indicia positioned on or below skin of the living subjectand in proximity to the biocompatible photonic device.
 20. (canceled)21. The system of claim 1, wherein the biocompatible photonic device isenclosed in a biocompatible packaging.
 22. The system of claim 1:wherein the biocompatible photonic device includes an optical-electricalconverter; and further comprising at least one device disposed withinthe living subject and operably coupled to the optical-electricalconverter to receive electrical energy therefrom.
 23. The system ofclaim 22, wherein the at least one device includes at least one of adrug delivery device, a micro-electro-mechanical device, a boneextension device, a biosensor, or a neurostimulator.
 24. The system ofclaim 1: wherein the biocompatible photonic device includes anoptical-electrical converter configured to convert one or more opticalpower signals, transmitted transdermally into the living subject, intoelectrical energy; and further comprising: an energy-storage devicecoupled to the optical-electrical converter to receive and store theelectrical energy; and at least one device coupled to the energy-storagedevice to receive the electrical energy therefrom.
 25. (canceled) 26.The system of claim 1, wherein the biocompatible photonic deviceincludes an optical-electrical converter configured to convert one ormore optical power signals, transmitted transdermally, into the livingsubject into electrical energy.
 27. The system of claim 1, wherein thebiocompatible photonic device includes an electrical-optical converterconfigured to convert one or more electrical signals into one or moreoptical power signals transdermally transmittable out of the livingsubject.
 28. The system of claim 1, wherein the photonic device isdisposed within the living subject.
 29. A method, comprising:transmitting one or more first signals to a living subject; andresponsive to the transmitting, receiving one or more second signalstransmitted from the living subject indicative of a location of aphotonic device disposed within the living subject.
 30. The method ofclaim 29, wherein transmitting one or more first signals to a livingsubject includes transmitting the one or more first signalstransdermally into the living subject.
 31. The method of claim 29,wherein receiving one or more second signals transmitted from the livingsubject indicative of a location of a photonic device disposed withinthe living subject includes receiving the one or more second signalstransmitted transdermally out of the living subject.
 32. The method ofclaim 29, wherein: transmitting one or more first signals to a livingsubject includes transmitting one or more optical signals to the livingsubject; and receiving one or more second signals transmitted from theliving subject indicative of a location of a photonic device disposedwithin the living subject includes receiving at least one of the one ormore optical signals reflected from a retroreflector positioned at leastproximate to the photonic device.
 33. The method of claim 29, wherein:transmitting one or more first signals to a living subject includestransmitting one or more first radio-frequency signals to the livingsubject; and receiving one or more second signals transmitted from theliving subject indicative of a location of a photonic device disposedwithin the living subject includes receiving one or more secondradio-frequency signals transmitted from a radio-frequency deviceencoding the location of the photonic device.
 34. (canceled)
 35. Themethod of claim 29, wherein receiving one or more second signalstransmitted from the living subject indicative of a location of aphotonic device disposed within the living subject includes receivingone or more optical signals transmitted from a transmitter encoding thelocation of the photonic device.
 36. The method of claim 29, whereintransmitting one or more first signals to a living subject includestransmitting the one or more first signals at a target positioned atleast proximate to the living subject.
 37. The method of claim 36,wherein transmitting the one or more first signals at a targetpositioned at least proximate to the living subject includestransmitting the one or more first signals at a reflective structurepositioned on or below skin of the living subject.
 38. The method ofclaim 36, wherein transmitting the one or more first signals at a targetpositioned at least proximate to the living subject includestransmitting the one or more first signals at a target positioned onclothing worn by the living subject.
 39. (canceled)
 40. (canceled) 41.The method of claim 29, wherein the photonic device includes anoptical-electrical converter.
 42. The method of claim 41, furthercomprising: responsive to the receiving the one or more second signals,transmitting one or more optical power signals to the optical-electricalconverter.
 43. The method of claim 29, wherein the photonic deviceincludes an electrical-optical converter.
 44. The method of claim 43,further comprising: responsive to the receiving the one or more secondsignals, receiving one or more optical power signals with theelectrical-optical converter.
 45. The method of claim 29, wherein thephotonic device is biocompatible.
 46. A method, comprising: receivingone or more first signals transmitted from a living subject; targetingan optical-electrical converter disposed within the living subject basedat least partially on information associated with the one or more firstsignals; and transmitting one or more optical power signalstransdermally into the living subject and to the targetedoptical-electrical converter.
 47. The method of claim 46, whereinreceiving one or more first signals transmitted from a living subjectincludes receiving one or more optical signals reflected from aretroreflector positioned at least proximate to the optical-electricalconverter and transmitted from the living subject.
 48. The method ofclaim 46, wherein receiving one or more first signals transmitted from aliving subject includes receiving one or more first optical signalsencoding a location of the optical-electrical converter.
 49. The methodof claim 46, wherein receiving one or more first signals from a livingsubject includes receiving one or more first radio-frequency signalsencoding a location of the optical-electrical converter.
 50. (canceled)51. The method of claim 46, wherein targeting an optical-electricalconverter disposed within the living subject based at least partially oninformation associated with the one or more first signals includesaiming an optical power source configured to output the one or moreoptical power signals at the optical-electrical converter. 52.(canceled)
 53. (canceled)
 54. The method of claim 46, whereintransmitting one or more optical power signals transdermally into theliving subject and to the targeted photonic device includes transmittingthe one or more optical power signals at a target positioned at leastproximate to the living subject.
 55. The method of claim 54, whereintransmitting the one or more optical power signals at a targetpositioned at least proximate to the living subject includestransmitting the one or more optical power signals at one or moreindicia positioned on or below skin of the living subject.
 56. Themethod of claim 54, wherein transmitting the one or more optical powersignals at a target positioned at least proximate to the living subjectincludes transmitting the one or more optical power signals at a targetpositioned on clothing worn by the living subject.
 57. A method,comprising: receiving one or more first signals transmitted from aliving subject; locating an electrical-optical converter disposed withinthe living subject based at least partially on information associatedwith the one or more first signals; and receiving one or more opticalpower signals transmitted transdermally out of the living subject and toan external device.
 58. The method of claim 57, wherein receiving one ormore first signals transmitted from a living subject includes receivingone or more optical signals reflected from a retroreflector positionedat least proximate to the electrical-optical converter and transmittedfrom the living subject.
 59. The method of claim 57, wherein receivingone or more first signals transmitted from a living subject includesreceiving one or more first optical signals encoding a location of theelectrical-optical converter.
 60. The method of claim 57, whereinreceiving one or more first signals from a living subject includesreceiving one or more first radio-frequency signals encoding a locationof the electrical-optical converter.
 61. (canceled)
 62. (canceled) 63.(canceled)
 64. (canceled)
 65. A method, comprising: transmitting one ormore signals from a living subject that are indicative of a location ofan optical-electrical converter disposed within the living subject;receiving one or more optical power signals with the optical-electricalconverter, which are transmitted transdermally into the living subjectresponsive to the transmitting; and converting the one or more opticalpower signals into electrical energy using the optical-electricalconverter.
 66. The method of claim 65, further comprising powering atleast one device disposed within the living subject using the electricalenergy.
 67. The method of claim 65, wherein the at least one deviceincludes at least one of a drug delivery device, amicro-electro-mechanical device, a bone extension device, a biosensor,or a neurostimulator.
 68. (canceled)
 69. (canceled)
 70. The method ofclaim 66, further comprising storing the electrical energy prior topowering the at least one device.
 71. (canceled)
 72. The method of claim65, wherein transmitting one or more signals from a living subject thatare indicative of a location of an optical-electrical converter disposedwithin the living subject includes reflecting the one or more signalsfrom a location-indicating aid disposed at least proximate to theoptical-electrical converter.
 73. The method of claim 65, whereintransmitting one or more signals from a living subject that areindicative of a location of an optical-electrical converter disposedwithin the living subject includes transmitting one or moreradio-frequency signals that encode the location of theoptical-electrical converter.
 74. The method of claim 65, whereintransmitting one or more signals from a living subject that areindicative of a location of an optical-electrical converter disposedwithin the living subject includes transmitting one or more opticalsignals that encode the location of the optical-electrical converter.75.-115. (canceled)